FAQs

PREMARIN MARES AND FOALS
Frequently Asked Questions

Who makes Premarin and Prempro?

Wyeth Pharmaceuticals, who first manufactured and produced the Premarin family of hormone replacement therapy (HRT) drugs for the treatment of menopausal symptoms in women, were bought out in 2009, and now a Division of Pfizer.

What are PMU's?

Premarin stands for Pre(gnant) Mar(e's) (Ur)in(e) and commonly referred to as PMU. These drugs are made with conjugated equine estrogens (CEE), and commonly sold under the names Premarin, Prempro and Premphase.

How is Premarin made?

Mares are kept pregnant, given little water to increase the concentration of estrogens in their urine, kept standing in stalls so small they cannot lie down to rest, and milked continuously in these conditions until they are ready to foal. The only time they are free is when they are taken offline to give birth. PMU mares are then turned out into fields so they can be impregnated for another cycle.  Although the average lifespan is 24, PMU mares live to be around 8 years old.

Where do the horses go when they can no longer produce?

When used up, PMU mares are sent to auction where, except a small percentage who are bought and taken in by a horse rescue or sanctuary, they are bought by killer buyers and end their lives in a slaughterhouse. Nearly every foal produced dies the same way. A number of these foals are shipped live to countries like Japan where their tender young meat is prized for making sushi (called basashi).

Introduced in the 1950's, this means that hundreds of thousands, possibly millions, of beautiful, innocent foals have been martyred for the production of Premarin and its sister drugs.

Is Premarin and Prempro safe?

Premarin and Prempro are proven to cause or enhance the development of various cancers in the breast and ovaries, among other life threatening diseases such as blood clots. Inevitably, the lawsuits followed. Wyeth have settled a large percentage of them, with sealed judgments so the public cannot know the extent of damages proved or amounts paid out.

As word spread, the market began to downsize significantly, although reports said at the time that Wyeth have drums and drums of pregnant mare's urine in storage to continue to sell the drugs.

So, are the drugs still sold?

Although some women refused to take Premarin and Prempro because of cruelty to horses, it was the threat to women's health that ultimately caused the sales of these drugs to decline.

Declines in sales and the closing of PMU ranches in North America meant a decline in activism against the PMU industry, with the issue attracting little attention.

However, sales are brisk again, especially with the advent of online marketing where people can buy Premarin and Prempro easily, cheaply and without a prescription.

The increase in sales of Premarin and Prempro does not mean, however, that Pfizer is re-opening PMU ranches in North America. They decided instead to set up PMU collection ranches in countries such as China, Kazakhstan and Poland – countries where horse slaughter and the human consumption of horse and foal meat is accepted and animal advocacy virtually nil.

 

What can women do?
  • DON'T TAKE IT ANYMORE  . . . . OR EVER START!

Refuse Premarin and Prempro if your doctor tries to prescribe them, and say why.

If your doctor tries try to dismiss your reasons for refusing Premarin and Prempro, stick to your guns.  Doctors are often given financial incentives to recommend drugs, or they may simply not care.

However, considering the serious risks of taking medications made with conjugated equine estrogens, you might want to consider going to another doctor!

Want to do more?  Please see our Patient to Doctor Letter campaign.

  • TAKE AN ALTERNATIVE

There are other HRT drugs available that are organic, safe and effective for the relief of menopausal symptoms. A quick search on the internet will give you the information you need to make a decision that is kind to horses, and to women.

See our Alternatives to Premarin and Prempro page.

  • SPREAD THE WORD

Be sure to warn the women in your life, and men too (see Aprela).  Share this page to raise even more awareness (buttons at the bottom).

We would also be delighted to receive a donation from you for our Premarin Billboard Campaign.

What about Aprela? 

Ah, Aprela. What a lovely sounding name. It doesn't sound deadly does it, or like it is related to Wyeth's Premarin family of drugs? But it is.

In October 2009, the Int'l Fund for Horses broke the news to horse advocates in an article in Tuesday's Horse that Wyeth have a new drug made with conjugated equine estrogen (pregnant mare's urine awaiting final approval by the FDA called Aprela.

Word is Pfizer is planning to market Aprela (if they can ever get it approved) as an osteoporosis relieving drug to both men and women.  Men will probably not realize they are taking a women's hormone replacement drug too.